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Title: Synthesis, characterization and antimicrobial activity of benzo[d]isoxazo-3-yl-(N-4-oxo-2-phenylthiazolidin-3-yl)acetamide derivatives
Authors: Merwade, Hiralal Y
Sunagar, Manjunath G
Belavagi, Ningaraddi S
Deshapande, Narahari
Gaonkar, Supreet
Khazi, Imtiyaz Ahmed M
Keywords: Antimicrobial activity;Benzoisoxazole;Nutrient agar;Thiazolidinone;Acid hydrazide
Issue Date: May-2017
Publisher: NISCAIR-CSIR, India
Abstract: In the present study we have synthesized a novel series of benzo[d]isoxazo-3-yl-(N-4-oxo-2-phenylthiazolidin-3-yl)acetamides 5a-j by the condensation of benzo[d]isoxazol-3-acetohydrazides 3a-b with various aromatic aldehydes in the presence of catalytic amount of acetic acid followed by treating the intermediate benzo[d]isoxazol-3-yl acetic acid arylidine hydrazides 4a-j with thioacetic acid in presence of anhydrous zinc chloride in DMF. The structures of the newly synthesized compounds have been well established by spectral and elemental analysis. Further, the synthesized compounds have been screened for their in vitro antibacterial assayagainst both gram positive and gram negative bacterial strains and the results are compared with the standard antibiotic drug Streptomycin using micro dilution method. The present study has revealed that the compounds containing −NO2 and −F groups show enhanced antibacterial activity.
Page(s): 560-566
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.56B(05) [May 2017]

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