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Title: Synthesis of Dihydropyran Derivatives and Evaluation of their Antibacterial Activity
Authors: Hao, Wen-Jing
Xu, Xiao-Yan
Zhang, Dai-Zun
Han, Rui
Keywords: Pyran;Crystal;Antibacterial
Issue Date: May-2017
Publisher: NISCAIR-CSIR, India
Abstract: As the persistent resistance of Staphylococcus aureus to available antibiotics is associated with high infection incidence, mortality rate and treatment cost, novel antibacterial agents with innovative therapeutic targets must be developed. Four novel pyran derivatives (1-4) were synthesized and characterized via IR, 1H NMR, HRMS, and single crystal X-ray crystallography. The antibacterial activities of the four compounds were investigated against Salmonella paratyphi A and Enterococcus faecalis by MIC and MBC assay. It was found that compared with compounds 1 and 2, compounds 3 and 4 exerted rather potent activities against the two cell lines.
Page(s): 299-302
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Appears in Collections:JSIR Vol.76(05) [May 2017]

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