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Title: In vitro antimicrobial activity of essential oils and their acetylenic constituents
Authors: Kumar, Vinod
Mathela, C S
Tewari, Geeta
Panwar, Amit
Pandey, Veena
Keywords: Asteraceae;Antibacterial activity;Essential oils;(Z)-lachnophyllum ester;2(E);8(Z)-matricaria ester
Issue Date: Mar-2017
Publisher: NISCAIR-CSIR, India
IPC Code: Int. cl. (2015.01)− A61K 36/00, A61P
Abstract: The emergence of new infections and increase of bacterial drug resistance has prompted interest for the development of new antibacterial agents from natural sources.This study is an attempt to assess the therapeutic potential of plant constituents as new antimicrobial drugs. The essential oils from six Asteraceae species belonging to the genus Erigeron, Aster, and Senecio were evaluated for their antibacterial activity against six bacteria namely Pseudomonas aeruginosa, Bacillus subtilis, Escherichia coli, Aeromonas hydrophilla, Klebsiella pneumonia, and Streptomyces candidus using agar well diffusion method. The results revealed (Z)-lachnophyllum (<68 %) and 2(E), 8(Z)-matricaria esters (<62 %) as the major acetylenic constituents in four Erigeron species. E. mucronatus showed the highest activity against Gram-positive bacteria S. candidus (8.3 mm, MIC 5 µL/mL) and B. subtilis (11.0 mm, MIC 10 µL/mL). (Z)-Lachnophyllum and 2(E), 8(Z)-matricaria esters showed maximum activity against S. candidus (MICs 5 µL/mL). The results showed that the oils containing acetylenic constituents have potential as natural agents for treatment of infections caused by these bacteria.
Page(s): 63-68
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.8(1) [March 2017]

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