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Title: Clean and one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thione derivatives using maleic acid as an efficient and environmentally benign natural di-functional Brønsted acid catalyst under solvent-free conditions
Authors: Maghsoodlou, Malek Taher
Heydari, Reza
Lashkari, Mojtaba
Mohamadpour, Farzaneh
Keywords: Maleic acid;Efficient catalyst;3,4-dihydropyrimidinone/thione;Biginelli reaction;Solvent-free conditions;Eco-friendly synthesis
Issue Date: Feb-2017
Publisher: NISCAIR-CSIR, India
Abstract: An efficient synthesis of Biginelli-type compounds using maleic acid as an economical di-functional Brønsted acid catalyst in a one-pot, three-component reaction of β-ketoesters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehye derivatives) and urea or thiourea is reported. The present methodology is an environmental friendly approach to access 3,4-dihydropyrimidin-2-(1H)-ones/tiones derivatives. It offers several merits such as good yields, short reaction times, efficient, eco-friendly, solvent-free conditions, materials available, and simple operational procedure with no column chromatographic separation. The products have been characterized by melting points and 1H NMR spectroscopy.
Page(s): 160-164
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.56B(02) [February 2017]

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