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|Title:||Synthesis and characterization of RS-4-amino-3-(4-chlorophenyl)-butyric acid: Baclofen impurity-A as per Indian Pharmacopoeia|
Sahu, Puran L
Singh, G N
|Abstract:||Baclofen, a gamma-amino butyric acid (GABA) derivative is mostly used to treat spasticity, alcoholism and hiccups. It contains a potential impurity namely baclofen impurity-A as per Indian Pharmacopoeia and other official compendiums. The objective of the present study is to synthesize and characterize baclofen impurity-A with the help of sophisticated analytical techniques like Fourier-Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), Thermo-Gravimetric Analysis (TGA), Nuclear Magnetic Resonance (NMR), Liquid Chromatography Mass Spectrometry (LC-MS), Elemental Analyzer (CHN), High Performance Liquid Chromatography (HPLC) and Gas Chromatography Head Space (GC-HS). Results show that baclofen impurity can be obtained in the purest form (>99.0%) to provide a reference standard.|
|Appears in Collections:||IJC-B Vol.56B(02) [February 2017]|
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