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Title: Synthesis and characterization of RS-4-amino-3-(4-chlorophenyl)-butyric acid: Baclofen impurity-A as per Indian Pharmacopoeia
Authors: Nandi, Utpal
Trikha, Shweta
Wadhwa, Aparna
Prakash, Anuj
Kumar, Robin
Sahu, Puran L
Singh, G N
Keywords: Baclofen;Baclofen impurity-A;FT-IR;NMR;LC-MS;HPLC
Issue Date: Feb-2017
Publisher: NISCAIR-CSIR, India
Abstract: Baclofen, a gamma-amino butyric acid (GABA) derivative is mostly used to treat spasticity, alcoholism and hiccups. It contains a potential impurity namely baclofen impurity-A as per Indian Pharmacopoeia and other official compendiums. The objective of the present study is to synthesize and characterize baclofen impurity-A with the help of sophisticated analytical techniques like Fourier-Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), Thermo-Gravimetric Analysis (TGA), Nuclear Magnetic Resonance (NMR), Liquid Chromatography Mass Spectrometry (LC-MS), Elemental Analyzer (CHN), High Performance Liquid Chromatography (HPLC) and Gas Chromatography Head Space (GC-HS). Results show that baclofen impurity can be obtained in the purest form (>99.0%) to provide a reference standard.
Page(s): 165-170
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.56B(02) [February 2017]

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