Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/40520
Title: Synthesis, characterization and antimicrobial activity of some 2,4-dibromo-1,5-dimorpholino/dipiperidino-pentane-3-ones
Authors: Joshi, Rahul
Sharma, Jaimala
Anita
Pardasani, R T
Keywords: Aldol condensation;Microwave technique;Grindstone technique;Ultrasound;Antimicrobial activity
Issue Date: Feb-2017
Publisher: NISCAIR-CSIR, India
Abstract: Condensation of acetone (2) with appropriate arylaldehydes (1) in the presence of ethanolic NaOH solution afforded 1,5-diarylpenta-1,4-diene-3-ones (3) which were subjected to bromination under controlled conditions to give 1,2,4,5-tetrabromo-1,5-diarylpentan-3-ones (4). Treatment of (4) with NH-heterocyclic base such as morpholine / piperidine in dry THF afforded the title compound in moderate yield. All the newly synthesized compounds were characterized on the basis of their spectral (IR, 1H NMR, MS) and analytical data. Some of the newly synthesized compounds showed moderate to high antimicrobial activity.
Page(s): 183-191
URI: http://nopr.niscair.res.in/handle/123456789/40520
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.56B(02) [February 2017]

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