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Title: Inhibition of local effects of Indian Daboia/Vipera russelli venom by the methanolic extract of grape (Vitis vinifera L.) seeds
Authors: Mahadeswaraswamy, Y H
Devaraja, S
Kumar, M S
Goutham, Y N J
Kemparaju, K
Keywords: Hyaluronidase;Local effects;Metalloprotease;Neutralization;Snake venom;Proteolytic activity;Hemorrhagic activity;Edema-inducing activity;Myonecrotic activity;Fibrinogenolytic activity;Pro-coagulant activity;Daboia russelli;Vipera russelli;Grape seed;Vitis vinifera L.
Issue Date: Apr-2009
Publisher: CSIR
Abstract:  Although anti-venom therapy is available for the treatment of fatal bite by snakes, it offers less or no protection against the local effects such as dermo- and myonecrosis, edema, hemorrhage and inflammation at the bitten region. The viper species are known for their violent local effects and such effects have been commonly treated with plant extracts without any scientific validation in rural India. In this investigation, the methanolic extract of grapes (Vitis vinifera L.) seed was studied against the Indian Daboia/Vipera russelli venom-induced local effects. The extract abolished the proteolytic and hyaluronidase activities and also efficiently neutralized the hemorrhage, edema-inducing and myonecrotic properties of the venom. In addition, the extract also inhibited partially the pro-coagulant activity of the venom and abolished the degradation of Aα and Bβ chains of human fibrinogen. Thus, the extract possesses potent anti-snake venom property, especially against the local effects of viper bites.
Page(s): 154-160
ISSN: 0301-1208
Appears in Collections:IJBB Vol.46(2) [April 2009]

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