NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.46 [2009] >
IJBB Vol.46(2) [April 2009] >


Title: Inhibition of local effects of Indian Daboia/Vipera russelli venom by the methanolic extract of grape (Vitis vinifera L.) seeds
Authors: Mahadeswaraswamy, Y H
Devaraja, S
Kumar, M S
Goutham, Y N J
Kemparaju, K
Keywords: Hyaluronidase
Local effects
Metalloprotease
Neutralization
Snake venom
Proteolytic activity
Hemorrhagic activity
Edema-inducing activity
Myonecrotic activity
Fibrinogenolytic activity
Pro-coagulant activity
Daboia russelli
Vipera russelli
Grape seed
Vitis vinifera L.
Issue Date: Apr-2009
Publisher: CSIR
Abstract:  Although anti-venom therapy is available for the treatment of fatal bite by snakes, it offers less or no protection against the local effects such as dermo- and myonecrosis, edema, hemorrhage and inflammation at the bitten region. The viper species are known for their violent local effects and such effects have been commonly treated with plant extracts without any scientific validation in rural India. In this investigation, the methanolic extract of grapes (Vitis vinifera L.) seed was studied against the Indian Daboia/Vipera russelli venom-induced local effects. The extract abolished the proteolytic and hyaluronidase activities and also efficiently neutralized the hemorrhage, edema-inducing and myonecrotic properties of the venom. In addition, the extract also inhibited partially the pro-coagulant activity of the venom and abolished the degradation of Aα and Bβ chains of human fibrinogen. Thus, the extract possesses potent anti-snake venom property, especially against the local effects of viper bites.
Page(s): 154-160
ISSN: 0301-1208
Source:IJBB Vol.46(2) [April 2009]

Files in This Item:

File Description SizeFormat
IJBB 46(2) 154-160.pdf838.79 kBAdobe PDFView/Open
 Current Page Visits: 714 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 624295 since 06-Feb-2009  Last updated on 13-Nov-2014Webmaster: nopr@niscair.res.in