NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.46B [2007] >
IJC-B Vol.46B(02) [February 2007] >


Title: Asymmetric synthesis of (R)-(–)-baclofen via asymmetric dihydroxylation
Authors: Thakur, V V
Paraskar, A S
Sudalai, A
Keywords: Asymmetric dihydroxylation
Baclofen
ϒ-aminobutyric acid
Parkinsons’ disease
Cyclic sulfate
Issue Date: Feb-2007
Publisher: CSIR
IPC CodeInt.Cl.⁸ C07C
Abstract: A short and efficient asymmetric synthesis of (R)-(–)-baclofen, a selective GABAB agonist has been described with an overall yield of 14% and 85% ee. The Os-catalyzed Sharpless asymmetric dihydroxylation of ⍺,β-unsaturated olefin constitutes the key step in introducing stereogenic centers into the molecule.
Page(s): 326-330
ISSN: 0367-4699
Source:IJC-B Vol.46B(02) [February 2007]

Files in This Item:

File Description SizeFormat
IJCB 46B(2) (2007) 326-330.pdf63.46 kBAdobe PDFView/Open
 Current Page Visits: 666 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 620845 since 06-Feb-2009  Last updated on 13-Nov-2014Webmaster: nopr@niscair.res.in