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IJC-B Vol.46B [2007] >
IJC-B Vol.46B(02) [February 2007] >

Title: Asymmetric synthesis of (R)-(–)-baclofen via asymmetric dihydroxylation
Authors: Thakur, V V
Paraskar, A S
Sudalai, A
Keywords: Asymmetric dihydroxylation
ϒ-aminobutyric acid
Parkinsons’ disease
Cyclic sulfate
Issue Date: Feb-2007
Publisher: CSIR
IPC CodeInt.Cl.⁸ C07C
Abstract: A short and efficient asymmetric synthesis of (R)-(–)-baclofen, a selective GABAB agonist has been described with an overall yield of 14% and 85% ee. The Os-catalyzed Sharpless asymmetric dihydroxylation of ⍺,β-unsaturated olefin constitutes the key step in introducing stereogenic centers into the molecule.
Page(s): 326-330
ISSN: 0367-4699
Source:IJC-B Vol.46B(02) [February 2007]

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