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dc.contributor.authorSulekha, S Mary Princess-
dc.contributor.authorReddy, G Aadhinaath-
dc.contributor.authorMuthuvel, A-
dc.identifier.issn0975-1068 (Online); 0972-5938 (Print)-
dc.description.abstractKayakarpam is one of the unique therapeutic formulation in Siddha system of medicine advocated for rejuvenation, longevity and elimination of disease causing factors. Karisalai Chooranam (KSC) is one of the Kayakarpam preparations described in Siddha medicine literature namely Bogamunivar Vaidya Kaviyam-1000. Karisalai Chooranam comprises equal proportion of six herbs such as Eclipta alba L. (Asteraceae), Acalypha indica L. (Euphorbiaceae), Sphaeranthus indicus L. (Compositae), Indigofera tinctoria L. (Fabaceae), Centella asiatica L. (Umbelliferae) and Wedelia chinensis (Asteraceae). Standardization and identification of marker compounds for Karisalai Chooranam has not been carried out. In the present study, the formulation has standardized by using standard physicochemical and phytochemical protocols as ash values, extractive values, chemical profiling; and marker quantification such as Wedelolactone, Quercetin, Asiaticoside and Rutin by using HPTLC finger printing. In addition, residue analyses (heavy metal content) by ICP-MS and pesticide analysis by LC-MS/MS were also carried out to strengthen the standardization process. Qualitative phytochemical screening revealed the presence of flavonoids, terpenes, steroids, saponins and cardiac glycosides. Microbial load, pesticide residues and heavy metals were found to be within permissible limits. The results are indicative of active ingredients responsible for therapeutic effect of KSC, thereby this study lends to the evidence for future pharmacological studies.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.relation.ispartofseriesInt. Cl8: A61K 36/00, C07, C08, C07C-C07Ken_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJTK Vol.16(2) [April 2017]en_US
dc.subjectKarisalai Chooranamen_US
dc.titlePhysicochemical and phytochemical standardization of polyherbal Siddha formulation ‘Karisalai Chooranam’en_US
Appears in Collections:IJTK Vol.16(2) [April 2017]

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