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Title: Physicochemical and phytochemical standardization of polyherbal Siddha formulation ‘Karisalai Chooranam’
Authors: Sulekha, S Mary Princess
Reddy, G Aadhinaath
Muthuvel, A
Keywords: Standardization;Karisalai Chooranam;HPTLC;Wedelolactone;Quercetin;Asiaticoside;Rutin
Issue Date: Apr-2017
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl8: A61K 36/00, C07, C08, C07C-C07K
Abstract: Kayakarpam is one of the unique therapeutic formulation in Siddha system of medicine advocated for rejuvenation, longevity and elimination of disease causing factors. Karisalai Chooranam (KSC) is one of the Kayakarpam preparations described in Siddha medicine literature namely Bogamunivar Vaidya Kaviyam-1000. Karisalai Chooranam comprises equal proportion of six herbs such as Eclipta alba L. (Asteraceae), Acalypha indica L. (Euphorbiaceae), Sphaeranthus indicus L. (Compositae), Indigofera tinctoria L. (Fabaceae), Centella asiatica L. (Umbelliferae) and Wedelia chinensis (Asteraceae). Standardization and identification of marker compounds for Karisalai Chooranam has not been carried out. In the present study, the formulation has standardized by using standard physicochemical and phytochemical protocols as ash values, extractive values, chemical profiling; and marker quantification such as Wedelolactone, Quercetin, Asiaticoside and Rutin by using HPTLC finger printing. In addition, residue analyses (heavy metal content) by ICP-MS and pesticide analysis by LC-MS/MS were also carried out to strengthen the standardization process. Qualitative phytochemical screening revealed the presence of flavonoids, terpenes, steroids, saponins and cardiac glycosides. Microbial load, pesticide residues and heavy metals were found to be within permissible limits. The results are indicative of active ingredients responsible for therapeutic effect of KSC, thereby this study lends to the evidence for future pharmacological studies.
Page(s): 263-269
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.16(2) [April 2017]

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