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Title: Synthesis of amide derivatives of quinolone and their antimicrobial studies
Authors: Patel, N B
Patel, A L
Chauhan, H I
Keywords: Amide;antimicrobial activity;cyclopropyl;imidazole;morpholine;piperazine;quinolone
Issue Date: Jan-2007
Publisher: CSIR
IPC Code: Int.Cl.⁸ C07D
Abstract: A series of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[chloro/1-piperazinyl/4-methyl-1-piperazinyl/4-ethyl-1-piperazinyl/ 4-hydroxyethyl-1-piperazinyl/imidazolyl/morpholinyl]-3[N-(substituted phenyl amino) carbonyl]quinoline 5-11a-j have been prepared by using substituted arylamine at C-3 position and 1-piperazine/4-methyl-1-piperazine/4-ethyl-1-piperazine/4-hydroxyethyl-1-piperazine/imidazole/morpholine at C-7 position of newly synthesized quinolone 3. Biological profile like antibacterial activity against four different strain viz. S. aureus and B. subtilis (gram-positive bacteria) and E. coli and P. aeruginosa (gram-negative bacteria) and C. albicans (fungi) by cup plate method have been studied.
Page(s): 126-134
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.46B(01) [January 2007]

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