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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.46B [2007] >
IJC-B Vol.46B(01) [January 2007] >
| Title: | Synthesis of amide derivatives of quinolone and their antimicrobial studies |
| Authors: | Patel, N B
Patel, A L
Chauhan, H I |
| Keywords: | Amide
antimicrobial activity
cyclopropyl
imidazole
morpholine
piperazine
quinolone |
| Issue Date: | Jan-2007 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.⁸ C07D |
| Abstract: | A series of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[chloro/1-piperazinyl/4-methyl-1-piperazinyl/4-ethyl-1-piperazinyl/ 4-hydroxyethyl-1-piperazinyl/imidazolyl/morpholinyl]-3[N-(substituted phenyl amino) carbonyl]quinoline 5-11a-j have been prepared by using substituted arylamine at C-3 position and 1-piperazine/4-methyl-1-piperazine/4-ethyl-1-piperazine/4-hydroxyethyl-1-piperazine/imidazole/morpholine at C-7 position of newly synthesized quinolone 3. Biological profile like antibacterial activity against four different strain viz. S. aureus and B. subtilis (gram-positive bacteria) and E. coli and P. aeruginosa (gram-negative bacteria) and C. albicans (fungi) by cup plate method have been studied. |
| Page(s): | 126-134 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.46B(01) [January 2007]
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