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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.46B [2007] >
IJC-B Vol.46B(02) [February 2007] >
| Title: | Isothiazolo-fused quinoline analogues: Synthesis of isothiazolo [5, 4-b] quinolines and their oxidation products, 3[2H]-one-1, 1-dioxideisothiazolo [5, 4-b] quinolines from 2-chloro-3-formylquinolines |
| Authors: | Srivastava, A
Chandra, Atish
Singh, R M |
| Keywords: | Cyclisation
Oxidation
Oxime
Sodium sulfide
Hydrogen peroxide |
| Issue Date: | Feb-2007 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.⁸C07D |
| Abstract: | A convenient synthesis of isothiazolo[5,4-b]quinolines 2 is achieved in two steps from the reaction of 2-chloro-3-formylquinolines 1 with sodium sulfide and hydroxylamine sequences followed by cyclisation with acetic anhydride. The subsequent oxidation of 2 with H₂O₂ in acetic acid yields 3(2H)-one-1, 1-dioxideisothiazolo [5, 4-b] quinolines 3. |
| Page(s): | 303-307 |
| ISSN: | 0367-4699 |
| Source: | IJC-B Vol.46B(02) [February 2007]
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