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dc.contributor.authorPrakash, Om-
dc.contributor.authorPundeer, Rashmi-
dc.contributor.authorRanjan, Pooja-
dc.contributor.authorPannu, Kamaljeet-
dc.contributor.authorDhingra, Yogita-
dc.contributor.authorAneja, K R-
dc.description.abstractA mild, short and simple method for the small scale synthesis of pharmaceutically important 1,3-diaryl-4-cyanopyrazoles 3 is reported from acetophenone arylhydrazones 1 through a two step reaction. All the title compounds have been subjected to in vitro antibacterial testing against four pathogenic strains namely, S.aureus, B.subtilis (gram positive) and gram negative bacteria namely, P.aeruginosa and E.coli. Preliminary results indicate that most of them exhibited promising activity. Two compounds, namely 1-(4-methylphenyl)-3-(4-bromophenyl)-4-cyanopyrazole 3d and 1-(4-chlorophenyl)-3-phenyl-4-cyanopyrazole 3e from this series are found to be equipotent or more potent than the commercial antibiotics (Linezolid and Ciprofloxacin)en_US
dc.sourceIJC-B Vol.48B(04) [April 2009]en_US
dc.subjectVilsmeier-Haack reactionen_US
dc.subjectantibacterial activityen_US
dc.titleSynthesis and antibacterial activity of 1,3-diaryl-4-cyanopyrazolesen_US
Appears in Collections:IJC-B Vol.48B(04) [April 2009]

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