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Title: Synthesis and antibacterial activity of 1,3-diaryl-4-cyanopyrazoles
Authors: Prakash, Om
Pundeer, Rashmi
Ranjan, Pooja
Pannu, Kamaljeet
Dhingra, Yogita
Aneja, K R
Keywords: Vilsmeier-Haack reaction
antibacterial activity
Issue Date: Apr-2009
Publisher: CSIR
Abstract: A mild, short and simple method for the small scale synthesis of pharmaceutically important 1,3-diaryl-4-cyanopyrazoles <b>3</b> is reported from acetophenone arylhydrazones <b>1</b> through a two step reaction. All the title compounds have been subjected to <i>in vitro</i> antibacterial testing against four pathogenic strains namely, <i>S.aureus</i>, <i>B.subtilis</i> (gram positive) and gram negative bacteria namely, <i>P.aeruginosa</i> and <i>E.coli</i>. Preliminary results indicate that most of them exhibited promising activity. Two compounds, namely 1-(4-methylphenyl)-3-(4-bromophenyl)-4-cyanopyrazole <b>3d</b> and 1-(4-chlorophenyl)-3-phenyl-4-cyanopyrazole <b>3e</b> from this series are found to be equipotent or more potent than the commercial antibiotics (Linezolid and Ciprofloxacin)
Description: 563-568
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.48B(04) [April 2009]

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