NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(04) [April 2009] >

Title: Simple and rapid synthesis of Nα-urethane protected β-amino alcohols and peptide alcohols employing HATU
Authors: Sureshbabu, Vommina V
Sudarshan, N S
Chennakrishnareddy, G
Keywords: N-Fmoc-β-amino alcohols
Bsmoc-β-amino alcohols
Issue Date: Apr-2009
Publisher: CSIR
Abstract: The activation of the Nα-urethane protected (Fmoc-/Boc-/Z-/Bsmoc) α-amino acids employing 1-[bis(dimethylamino)­methylene]-1H-1,2,3-triazolo-[4,5-b]pyridinium.0hexa-flurophosphate-3-oxide (HATU) followed by reduction of the in situ generated –OAt ester with NaBH4 results in the corresponding β-amino alcohols in good yields. This synthesis is the first demonstration of the application of the efficient coupling agent HATU for practical synthesis of β-amino alcohols. The protocol is general for all common N-protecting groups including the highly base sensitive Bsmoc group. The protocol has also been successfully extended for the synthesis of peptide alcohols.
Page(s): 574-579
ISSN: 0376-4699
Source:IJC-B Vol.48B(04) [April 2009]

Files in This Item:

File Description SizeFormat
IJCB 48B(4) 574-579.pdf271.57 kBAdobe PDFView/Open
 Current Page Visits: 111 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 167017 since 01-Sep-2015  Last updated on 28-Jun-2016Webmaster: