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IJC-B Vol.48B [2009] >
IJC-B Vol.48B(04) [April 2009] >


Title: Synthesis of an amino moiety in trovafloxacin by using an in-expensive amidine base, N,N-diethylacetamidine
Authors: Madhusudhan, G
Balraju, V
Rajesh, T
Narayana, B Venkata
Reddy, R Naveen
Keywords: N,N-Diethylacetamidine
bicyclic hetero compounds
NaBH4/I2-THF
trovafloxacin
antibacterial agent
Issue Date: Apr-2009
Publisher: CSIR
Abstract:  The simple and in-expensive amidine base, N,N-diethylacetamidine, has been prepared and utilized in the construction of bicyclic hetero compound, 4 and employed for further reduction of amidic carbonyl groups of 4 by using NaBH4/I2-THF condition which is an efficient and commercially viable method to prepare 5 towards the synthesis of amino moiety 1, in Trovafloxacin 2 an antibacterial agent.
Page(s): 569-573
ISSN: 0376-4699
Source:IJC-B Vol.48B(04) [April 2009]

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