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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(04) [April 2009] >
| Title: | An efficient method for the synthesis of 2,3-dihydro-1H-isoindoles |
| Authors: | Subbarayappa, Adimurthy
Patoliya, Paresh U |
| Keywords: | ⍺,⍺'-Dibromo-o-xylene
amines
sodium hydroxide
2,3-dihydro-1H-isoindoles |
| Issue Date: | Apr-2009 |
| Publisher: | CSIR |
| Abstract: | The synthesis of
N-substituted 2,3-dihydro-1H-isoindoles from
⍺,
⍺'-dibromo-o-xylene and various
primary amines in basic medium under ambient conditions is described.
Especially the selection of 1,4-dioxane as solvent and sodium hydroxide as
suitable base to maintain the
homogeneity of the medium are key steps to promote the reaction
efficiently. Primary alkyl amines react faster as compared to their aromatic
analogues under the conditions studied. Irrespective of the starting amine
used, all the reactions proceed smoothly and provide 2,3-dihydro-1H-isoindoles
derivatives in excellent yields compared to hitherto known methods. |
| Page(s): | 545-552 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.48B(04) [April 2009]
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