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Title: Antimicrobial activities of fungi derived from the gorgonian sea fan Annella sp. & their metabolites
Authors: Preedanon, Sita
Phongpaichit, Souwalak
Sakayaroj, Jariya
Rukachaisirikul, Vatcharin
Khamthong, Nanthaphong
Trisuwan, Kongkiat
Plathong, Sakanan
Keywords: Sea fan-derived fungi;Antibacterial;Antifungal;Molecular identification;Griseofulvin
Issue Date: Nov-2016
Publisher: NISCAIR-CSIR, India
Abstract: One hundred and sixty-three fungi isolated from gorgonian sea fan Annella sp. were screened for antimicrobial activity against human pathogens. Forty-seven percents of the isolates produced antimicrobial metabolites against at least one pathogen with minimum inhibitory concentrations (MIC) ranged from 1 to 1,280 µg mL-1. Crude extracts from 16%, 21%, 18% and 23% of the isolates inhibited standard strain of Staphylococcus aureus, methicillin-resistant S. aureus, Escherichia coli and Pseudomonas aeruginosa, respectively. Eighteen percents of the isolates displayed antifungal activity against Microsporum gypseum while only 3% inhibited Cryptoccocus neoformans and Candida albicans. Potential isolates were identified by morphological and molecular characteristics. Twenty-nine pure compounds isolated from ten isolates were evaluated for antimicrobial activity. Griseofulvin from Nigrospora sp. PSU-F13 exhibited the best activity against M. gypseum (MIC 2 µg mL-1). The result indicates that sea fan-derived fungi are a potential source of antimicrobial agents.
Page(s): 1491-1498
ISSN: 0975-1033 (Online); 0379-5136 (Print)
Appears in Collections:IJMS Vol.45(11) [November 2016]

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