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IJEB Vol.47(04) [April 2009] >

Title: Hepatoprotective activity of six polyherbal formulations in CCl4-induced liver toxicity in mice
Authors: Girish, C
Koner, Bidhan Chandra
Jayanthi, S
Rao, K Ramachandra
Rajesh, B
Pradhan, Suresh Chandra
Keywords: CCl4
Centrizonal necrosis
Liver enzymes
Polyherbal formulations
Issue Date: Apr-2009
Publisher: CSIR
Abstract: To evaluate pretreatment of six polyherbal liquid formulations (PLFs) commercially available in India, on CCl4-induced liver injury, Swiss albino mice were treated for 7 days with distilled water or PLFs (2.6 and 5.2 ml/kg body weight/day, po) followed by single sc injection of 50% (v/v) CCl4 in arachis oil at a dose of 1ml/kg. The serum biochemical parameters such as alanine transaminases, aspartate transaminases and alkaline phosphatase were estimated. Phenobarbitone-induced sleeping time and liver histopathology were also carried out. CCl4-treated animals showed significant increase in the levels of liver enzymes, phenobarbitone-induced sleeping time and revealed fatty changes and centrizonal necrosis on histological examination of liver indicating hepatic damage. When pretreated with PLFs at a dose of 5.2 ml/kg body weight/day, the CCl4-induced changes were significantly reversed. The pretreatment with PLFs can prevent acute liver damage induced by CCl4 only at a higher dose. Therefore, it is suggested that a dose adjustment of these PLFs may be necessary for their optimal effects in human liver diseases.
Page(s): 257-263
ISSN: 0019-5189
Source:IJEB Vol.47(04) [April 2009]

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