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http://nopr.niscair.res.in/handle/123456789/3858
Title: | Hepatoprotective activity of six polyherbal formulations in CCl4-induced liver toxicity in mice |
Authors: | Girish, C Koner, Bidhan Chandra Jayanthi, S Rao, K Ramachandra Rajesh, B Pradhan, Suresh Chandra |
Keywords: | CCl4;Centrizonal necrosis;Hepatoprotective;Hepatotoxicity;Liver enzymes;Polyherbal formulations |
Issue Date: | Apr-2009 |
Publisher: | CSIR |
Abstract: | To evaluate pretreatment of six polyherbal liquid formulations (PLFs) commercially available in India, on CCl4-induced liver injury, Swiss albino mice were treated for 7 days with distilled water or PLFs (2.6 and 5.2 ml/kg body weight/day, po) followed by single sc injection of 50% (v/v) CCl4 in arachis oil at a dose of 1ml/kg. The serum biochemical parameters such as alanine transaminases, aspartate transaminases and alkaline phosphatase were estimated. Phenobarbitone-induced sleeping time and liver histopathology were also carried out. CCl4-treated animals showed significant increase in the levels of liver enzymes, phenobarbitone-induced sleeping time and revealed fatty changes and centrizonal necrosis on histological examination of liver indicating hepatic damage. When pretreated with PLFs at a dose of 5.2 ml/kg body weight/day, the CCl4-induced changes were significantly reversed. The pretreatment with PLFs can prevent acute liver damage induced by CCl4 only at a higher dose. Therefore, it is suggested that a dose adjustment of these PLFs may be necessary for their optimal effects in human liver diseases. |
Page(s): | 257-263 |
URI: | http://hdl.handle.net/123456789/3858 |
ISSN: | 0019-5189 |
Appears in Collections: | IJEB Vol.47(04) [April 2009] |
Files in This Item:
File | Description | Size | Format | |
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IJEB 47(4) 257-263.pdf | 846.59 kB | Adobe PDF | View/Open |
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