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IJC-B Vol.46B(07) [July 2007] >

Title: Synthesis of novel aliphatic thiourea derivatives containing s-triazine moiety as potential antimicrobial agents
Authors: Desai, Akshay D
Mahajan, Dharmesh H
Chikhalia, Kishor H
Keywords: Aliphatic thiourea
aryl urea
antibacterial activity
antifungal activity
Issue Date: Jul-2007
Publisher: CSIR
Abstract: A new series of aliphatic thiourea and various aryl urea incorporating 1,3,5-s-triazine moiety is reported. This series has been obtained by the reaction of cyanuric chloride with thiophene-2-ethyl thiourea 1. Thus, the prepared 2-(thiophene-2-ethyl thioureido)-4,6-dichloro-s-triazine 2 has been subsequently treated with morpholine to get 2-(thiophene-2-ethyl thioureido)-4-(morpholino)-6-chloro-s-triazine 3. This is further treated with various aryl ureas to afford title compound 4a-j. The library of ureido linkage containing triazinyl moiety has been tested for in vitro antibacterial and antifungal activity against different microorganisms. The structure of novel synthesized compounds has been established on the basis of elemental analysis, 1H NMR, IR and mass spectral data.
Page(s): 1169-1173
ISSN: 0376-4699
Source:IJC-B Vol.46B(07) [July 2007]

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