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Title: Synthesis of some new 2-(4-alkylthiophenoxy)-4-substituted-1, 3-thiazoles as possible anti-inflammatory and antimicrobial agents
Authors: T, Karabasanagouda
Adhikari, Airody Vasudeva
Dhanwad, Ramgopal
Parameshwarappa, G
Keywords: 2-{[4-(Alkylthio)phenoxy]methyl}-4-aryl-1;3-thia-zoles;4-(substitutedmethyl)-2-{[4-(alkylthio)phenoxy]meth-yl}- 1;3 thiazoles;anti-inflammatory activity;antibacterial;antifungal screening
Issue Date: Jan-2008
Publisher: CSIR
Abstract: A series of new 2-{[4-(alkylthio)phenoxy]methyl}-4-substi¬tuted-1,3-thiazoles 4a-q, 6a-j have been synthesized from ethyl [4-(alkylthio)phenoxy]acetates 1a,b through multi-step reaction sequence. The structures of new compounds have been esta¬blished on the basis of their elemental analysis and IR, 1H and 13C NMR and mass spectral data. Selected title compounds have been evaluated for anti-inflammatory activity and in vitro antibacterial testing against two pathogenic strains and antifungal screening against two fungi.
Page(s): 144-152
ISSN: 0376-4699
Appears in Collections: IJC-B Vol.47B(01) [January 2008]

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