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IJBB Vol.40(6) [December 2003] >

Title: Lipid peroxidation and scavenging enzyme levels in the liver of streptozotocin-induced diabetic rats
Authors: Bukan, Neslihan
Sancak, Banu
Yavuz, Ozlem
Koca, Cemile
Tutkun, Funda
Ozcelikay, A Tanju
Altan, Nilgun
Keywords: lipid peroxidation
antioxidant enzymes
diabetic rats
Issue Date: Dec-2003
Publisher: CSIR
Abstract: In this study, alterations in the liver antioxidant enzymes status and lipid peroxidation in short-term (8-weeks) and long-term (24-weeks) diabetic rats were examined. Glutathione peroxidase (GSH-Px) activity and malondialdehyde (MDA) levels were significantly increased, but superoxide dismutase (SOD) activity was significantly reduced in 8-weeks diabetic rats, compared to control. Catalase (CAT) activity, however, was found unchanged. In 24-weeks diabetic rats, while GSH-Px activity was unchanged, but SOD and CAT activities and MDA levels were significantly increased, compared to control. These results suggest that diabetes-induced alterations in tissue antioxidant system may reflect a generalized increase in tissue oxidative stress. It can be concluded that lipid peroxidation and antioxidant enzyme levels are elevated in diabetic condition. Hence, diabetes mellitus, if left untreated, may increase degenerative processes due to accumulation of oxidative free radicals.
Page(s): 447-450
ISSN: 0301-1208
Source:IJBB Vol.40(6) [December 2003]

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