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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.40 [2003] >
IJBB Vol.40(6) [December 2003] >
| Title: | Fibronectin dependent upregulation of matrix metalloproteinases in hepatic stellate cells |
| Authors: | Pranitha, P
Sudhakaran, P R |
| Keywords: | Hepatic stellate cells
fibronectin-dependent upregulation
matrix metalloproteinase |
| Issue Date: | Dec-2003 |
| Publisher: | CSIR |
| Abstract: | Activation and transition of hepatic stellate cells (HSCs) to myofibroblast (MFB)-like cells is influenced by growth factors, cytokines and matrix proteins like fibronectin (FN). To examine whether the FN-dependent transition of HSCs is mediated through FN receptor, a marker function, such as matrix metallo-proteinase (MMP) production by HSCs in primary culture was studied. An upregulation of MMP production by HSCs maintained on FN was observed. FN-dependent upregulation of MMPs was significantly reduced when cells were pre-treated with antibodies to ⍺5β1 integrin. Treatment of cells with genistein, a protein kinase C inhibitor completely blocked the gelatinase production by HSCs, indicating that the FN-dependent upregulation of MMPs is mediated through integrins and it involves tyrosine phosphorylation dependent signaling pathways. |
| Page(s): | 409-415 |
| ISSN: | 0301-1208 |
| Source: | IJBB Vol.40(6) [December 2003]
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