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Title: Fibronectin dependent upregulation of matrix metalloproteinases in hepatic stellate cells
Authors: Pranitha, P
Sudhakaran, P R
Keywords: Hepatic stellate cells
fibronectin-dependent upregulation
matrix metalloproteinase
Issue Date: Dec-2003
Publisher: CSIR
Abstract: Activation and transition of hepatic stellate cells (HSCs) to myofibroblast (MFB)-like cells is influenced by growth factors, cytokines and matrix proteins like fibronectin (FN). To examine whether the FN-dependent transition of HSCs is mediated through FN receptor, a marker function, such as matrix metallo-proteinase (MMP) production by HSCs in primary culture was studied. An upregulation of MMP production by HSCs maintained on FN was observed. FN-dependent upregulation of MMPs was significantly reduced when cells were pre-treated with antibodies to ⍺5β1 integrin. Treatment of cells with genistein, a protein kinase C inhibitor completely blocked the gelatinase production by HSCs, indicating that the FN-dependent upregulation of MMPs is mediated through integrins and it involves tyrosine phosphorylation dependent signaling pathways.
Page(s): 409-415
ISSN: 0301-1208
Source:IJBB Vol.40(6) [December 2003]

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