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|Title:||Fibronectin dependent upregulation of matrix metalloproteinases in hepatic stellate cells|
Sudhakaran, P R
|Keywords:||Hepatic stellate cells;fibronectin-dependent upregulation;matrix metalloproteinase|
|Abstract:||Activation and transition of hepatic stellate cells (HSCs) to myofibroblast (MFB)-like cells is influenced by growth factors, cytokines and matrix proteins like fibronectin (FN). To examine whether the FN-dependent transition of HSCs is mediated through FN receptor, a marker function, such as matrix metallo-proteinase (MMP) production by HSCs in primary culture was studied. An upregulation of MMP production by HSCs maintained on FN was observed. FN-dependent upregulation of MMPs was significantly reduced when cells were pre-treated with antibodies to ⍺5β1 integrin. Treatment of cells with genistein, a protein kinase C inhibitor completely blocked the gelatinase production by HSCs, indicating that the FN-dependent upregulation of MMPs is mediated through integrins and it involves tyrosine phosphorylation dependent signaling pathways.|
|Appears in Collections:||IJBB Vol.40(6) [December 2003]|
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