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dc.contributor.authorKaur, Jaspreet-
dc.contributor.authorSingh, Sangeeta-
dc.contributor.authorSharma, Deepak-
dc.contributor.authorSingh, Rameshwar-
dc.description.abstractWe investigated alterations in the ageing-related parameters: multiple-unit action potentials, Na+, K+-ATPase activity, glutathione-s-transferase (GST) activity, glutathione peroxidase (GPx) activity, lipid peroxidation and lipofuscin contents in the brain regions cerebral cortex, striatum, hippocampus and thalamus, resulting from the chronic administration of aluminium chloride (AlCl3 ) in drinking water to rats of 6 and 12 months of age. Aluminium treatment significantly depressed Na+, K+-ATPase, GST and GPx activities, elevated lipid peroxidation and lipofuscin contents, and produced intense epileptiform activity in the electroencephalograms of the studied brain regions together with a concomitant increase in the multiple-unit action potentials (MUA) indicating a vigorous neuronal epileptic hyperactivity. Taken together the aluminium-induced alterations in these parameters are indicative of an accelerated ageing process.en_US
dc.sourceIJBB Vol.40(5) [October 2003]en_US
dc.subjectbrain ageingen_US
dc.subjectmultiple unit action potentialsen_US
dc.subjectantioxidant enzymesen_US
dc.subjectlipid peroxidationen_US
dc.subjectepileptic activityen_US
dc.subjectacceleration of ageingen_US
dc.titleAluminium-induced enhancement of ageing-related biochemical and electrophysiological parameters in rat brain regionsen_US
Appears in Collections:IJBB Vol.40(5) [October 2003]

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