Please use this identifier to cite or link to this item:
|Title:||Aluminium-induced enhancement of ageing-related biochemical and electrophysiological parameters in rat brain regions|
|Keywords:||Aluminium;brain ageing;Na+;K+-ATPase;multiple unit action potentials;antioxidant enzymes;lipofuscin;lipid peroxidation;epileptic activity;acceleration of ageing|
|Abstract:||We investigated alterations in the ageing-related parameters: multiple-unit action potentials, Na+, K+-ATPase activity, glutathione-s-transferase (GST) activity, glutathione peroxidase (GPx) activity, lipid peroxidation and lipofuscin contents in the brain regions cerebral cortex, striatum, hippocampus and thalamus, resulting from the chronic administration of aluminium chloride (AlCl3 ) in drinking water to rats of 6 and 12 months of age. Aluminium treatment significantly depressed Na+, K+-ATPase, GST and GPx activities, elevated lipid peroxidation and lipofuscin contents, and produced intense epileptiform activity in the electroencephalograms of the studied brain regions together with a concomitant increase in the multiple-unit action potentials (MUA) indicating a vigorous neuronal epileptic hyperactivity. Taken together the aluminium-induced alterations in these parameters are indicative of an accelerated ageing process.|
|Appears in Collections:||IJBB Vol.40(5) [October 2003]|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.