|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.40 [2003] >
IJBB Vol.40(4) [August 2003] >
| Title: | Protective role of selenium status on T3/T4 kinetics in rats under hyperlipidemia |
| Authors: | Dhingra, Sanjiv
Singh, Uma
Bansal, M P |
| Keywords: | hyperlipidemia
hypothyroidism
lipid
T3/T4kinetics
selenium status
rats |
| Issue Date: | Aug-2003 |
| Publisher: | CSIR |
| Abstract: | The effect of high fat diet (HFD) on thyroid hormones (T3/T4 ) and protective role of selenium (Se) were studied in rats. Se levels in serum and liver decreased significantly, whereas glutathione peroxidase (GSH-Px) in liver and lipid levels (cholesterol and triglycerides) in serum increased after 1, 2 and 3 months of HFD feeding in comparison to controls in all the three Se status i.e. deficient (0.02 ppm), adequate (0.2 ppm) and excess (1 ppm) groups. Levels of T3/T4 decreased significantly on HFD feeding, as compared to respective controls in all the groups. Within the deficient group, as Se deficiency progressed, T3/T4 levels decreased after 2 and 3 months in comparison to 1 month. A significant increase was observed in T3/T4 concentration on feeding 1 ppm (excess) Se supplemented diet, in comparison to adequate group. Also, in 1 ppm Se supplemented group as the Se deposition increased i.e. after 2 and 3 months, levels of T3/T4 increased significantly. So, the present study indicates that Se supplementation up to 1 ppm normalizes the T3 and T4concentrations or regulates the hypothyroidism induced by hyperlipidemia. |
| Page(s): | 260-264 |
| ISSN: | 0301-1208 |
| Source: | IJBB Vol.40(4) [August 2003]
|
|
