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Title: Protective role of selenium status on T3/T4 kinetics in rats under hyperlipidemia
Authors: Dhingra, Sanjiv
Singh, Uma
Bansal, M P
Keywords: hyperlipidemia;hypothyroidism;lipid;T3/T4kinetics;selenium status;rats
Issue Date: Aug-2003
Publisher: CSIR
Abstract: The effect of high fat diet (HFD) on thyroid hormones (T3/T4 ) and protective role of selenium (Se) were studied in rats. Se levels in serum and liver decreased significantly, whereas glutathione peroxidase (GSH-Px) in liver and lipid levels (cholesterol and triglycerides) in serum increased after 1, 2 and 3 months of HFD feeding in comparison to controls in all the three Se status i.e. deficient (0.02 ppm), adequate (0.2 ppm) and excess (1 ppm) groups. Levels of T3/T4 decreased significantly on HFD feeding, as compared to respective controls in all the groups. Within the deficient group, as Se deficiency progressed, T3/T4 levels decreased after 2 and 3 months in comparison to 1 month. A significant increase was observed in T3/T4 concentration on feeding 1 ppm (excess) Se supplemented diet, in comparison to adequate group. Also, in 1 ppm Se supplemented group as the Se deposition increased i.e. after 2 and 3 months, levels of T3/T4 increased significantly. So, the present study indicates that Se supplementation up to 1 ppm normalizes the T3 and T4concentrations or regulates the hypothyroidism induced by hyperlipidemia.
Page(s): 260-264
ISSN: 0301-1208
Appears in Collections:IJBB Vol.40(4) [August 2003]

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