NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.40 [2003] >
IJBB Vol.40(4) [August 2003] >


Title: Protective role of selenium status on T3/T4 kinetics in rats under hyperlipidemia
Authors: Dhingra, Sanjiv
Singh, Uma
Bansal, M P
Keywords: hyperlipidemia
hypothyroidism
lipid
T3/T4kinetics
selenium status
rats
Issue Date: Aug-2003
Publisher: CSIR
Abstract: The effect of high fat diet (HFD) on thyroid hormones (T3/T4 ) and protective role of selenium (Se) were studied in rats. Se levels in serum and liver decreased significantly, whereas glutathione peroxidase (GSH-Px) in liver and lipid levels (cholesterol and triglycerides) in serum increased after 1, 2 and 3 months of HFD feeding in comparison to controls in all the three Se status i.e. deficient (0.02 ppm), adequate (0.2 ppm) and excess (1 ppm) groups. Levels of T3/T4 decreased significantly on HFD feeding, as compared to respective controls in all the groups. Within the deficient group, as Se deficiency progressed, T3/T4 levels decreased after 2 and 3 months in comparison to 1 month. A significant increase was observed in T3/T4 concentration on feeding 1 ppm (excess) Se supplemented diet, in comparison to adequate group. Also, in 1 ppm Se supplemented group as the Se deposition increased i.e. after 2 and 3 months, levels of T3/T4 increased significantly. So, the present study indicates that Se supplementation up to 1 ppm normalizes the T3 and T4concentrations or regulates the hypothyroidism induced by hyperlipidemia.
Page(s): 260-264
ISSN: 0301-1208
Source:IJBB Vol.40(4) [August 2003]

Files in This Item:

File Description SizeFormat
IJBB 40(4) 260-264.pdf78.61 kBAdobe PDFView/Open
 Current Page Visits: 459 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 511391 since 06-Feb-2009  Last updated on 11-Apr-2014Webmaster: nopr@niscair.res.in