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|Title:||Protective role of selenium status on T<sub>3</sub>/T<sub>4</sub> kinetics in rats under hyperlipidemia|
Bansal, M P
|Abstract:||The effect of high fat diet (HFD) on thyroid hormones (T<sub>3</sub>/T<sub>4</sub> ) and protective role of selenium (Se) were studied in rats. Se levels in serum and liver decreased significantly, whereas glutathione peroxidase (GSH-Px) in liver and lipid levels (cholesterol and triglycerides) in serum increased after 1, 2 and 3 months of HFD feeding in comparison to controls in all the three Se status i.e. deficient (0.02 ppm), adequate (0.2 ppm) and excess (1 ppm) groups. Levels of T<sub>3</sub>/T<sub>4</sub> decreased significantly on HFD feeding, as compared to respective controls in all the groups. Within the deficient group, as Se deficiency progressed, T<sub>3</sub>/T<sub>4</sub> levels decreased after 2 and 3 months in comparison to 1 month. A significant increase was observed in T<sub>3</sub>/T<sub>4</sub> concentration on feeding 1 ppm (excess) Se supplemented diet, in comparison to adequate group. Also, in 1 ppm Se supplemented group as the Se deposition increased i.e. after 2 and 3 months, levels of T<sub>3</sub>/T<sub>4</sub> increased significantly. So, the present study indicates that Se supplementation up to 1 ppm normalizes the T<sub>3</sub> and T<sub>4</sub>concentrations or regulates the hypothyroidism induced by hyperlipidemia.|
|Appears in Collections:||IJBB Vol.40(4) [August 2003]|
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