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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
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Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
NPR Vol.8 [2009] >
NPR Vol.8(1) [January-February 2009] >
| Title: | Antilithiatic activity of Hibiscus sabdariffa Linn. on ethylene glycol-induced lithiasis in rats |
| Authors: | Betanabhatla, Kalyan S
Christina, AJM
Sundar, B Syama
Selvakumar, S
Saravanan, K Sundara |
| Keywords: | Antilithiatic
Hibiscus sabdariffa
Roselle
Nephrolithiasis
Urolithiasis
Renal calculi
Ethylene glycol |
| Issue Date: | Feb-2009 |
| Publisher: | CSIR |
| IPC Code: | Int. cl.8—A61K 36/00, A61P 13/04 |
| Abstract: | The ethanolic extract of leaves of Hibiscus sabdariffa Linn. (EEHS) was evaluated
for its antilithiatic activity in rats. Lithiasis was induced by oral administration of ethylene glycolated
water (0.75 %) in adult male albino Wistar rats for 28 days. The ionic chemistry of urine was
altered by ethylene glycol (EG), which elevated the urinary concentration of crucial ions, viz.
calcium, phosphate, uric acid and oxalate thereby contributing to renal stone formation. The
EEHS, however, significantly (P< 0.05) reduced the elevated level of these ions in urine. Also, it
elevated concentration of urinary magnesium, which is considered as one of the inhibitors of
crystallization. All these observations revealed that EEHS has curative effect on stone formation
induced by ethylene glycol. |
| Page(s): | 43-47 |
| ISSN: | 0972-592X |
| Source: | NPR Vol.8(1) [January-February 2009]
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