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Title: Evaluation of the immunomodulatory activity of the methanolic extract of Couroupita guianensis Aubl. flowers in rats
Authors: Pradhan, D
Panda, P K
Tripathy, G
Keywords: Couroupita guianensis Allergic reaction;Hemagglutination;Immunostimulant;Lecythidaceae
Issue Date: Feb-2009
Publisher: CSIR
IPC Code: Int. cl.8— A61K 36/00, A61P 37/02
Abstract: Various extracts of the flowers of Couroupita guianensis Aubl. (Family-Lecythidaceae) were evaluated for potential immunomodulatory activity using the in vitro polymorphonuclear leukocyte function test (human neutrophils). The methanol extract was evaluated for immunomodulatory activity in in vivo studies, using rats as the animal model. The extracts were tested for hypersensitivity and hemagglutination reactions, using sheep red blood cells (SRBC) as the antigen. Distilled water served as a control in all the tests. The successive methanol and water extracts exhibited a significant increase in the percentage phagocytosis versus the control. In the in vivo studies, the successive methanol extract was found to exhibit a dose related increase in the hypersensitivity reaction, to the SRBC antigen, at concentration of 100 and 200 mg/kg in animal studies. The successive methanol extract was found to stimulate cell mediated and antibody mediated immune responses in rats. It also enhanced the phagocytic function of the human neutrophils, in vivo.
Page(s): 37-42
ISSN: 0972-592X
Appears in Collections:NPR Vol.8(1) [January-February 2009]

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