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Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
NPR Vol.8 [2009] >
NPR Vol.8(1) [January-February 2009] >
| Title: | Effect of alcoholic extract of roots of Dichrostachys cinerea Wight & Arn. against cisplatin-induced nephrotoxicity in rats |
| Authors: | Adikay, Sreedevi
Koganti, Bharathi
Prasad, KVSRG |
| Keywords: | Dichrostachys cinerea
Nephrotoxicity
Cisplatin
Antioxidant |
| Issue Date: | Feb-2009 |
| Publisher: | CSIR |
| IPC Code: | Int. cl.8— A61K 36/00, A61P 39/06 |
| Abstract: | The alcoholic extract of roots of Dichrostachys cinerea Wight & Arn. (200 and
400 mg/kg, p.o.) was studied for its protective effect against cisplatin-induced renal injury in rats.
Cisplatin (6mg/kg, i.p.) significantly elevated serum markers level, increased urinary protein
excretion, reduced urine to serum creatinine ratio and creatinine clearance. In curative regimen,
the alcoholic extract exhibited dose dependent protection. Animals which received prophylactic
treatment also showed partial protection against cisplatin-induced effects. Histopathological studies
substantiated the above results. Further, the alcoholic extract showed marked nitric oxide scavenging
effect and reducing power suggesting an antioxidant property. A triterpenoid, fatty acid and a
steroid were isolated from the n-hexane, ethyl acetate fractions of alcoholic extract. The results
suggested that the roots of D. cinerea showed protective effect against cisplatin-induced
nephrotoxicity which may probably be mediated by its antioxidant property. |
| Page(s): | 12-18 |
| ISSN: | 0972-592X |
| Source: | NPR Vol.8(1) [January-February 2009]
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