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|Title:||Wound healing activity of aqueous and methanolic bark extracts of Vernonia arborea Buch.-Ham. in Wistar rats|
Panda, P K
|Series/Report no.:||Int cl.8— A61K 36/00, A61P 17/02|
|Abstract:||Excision, incision and dead space wound models were used to evaluate the wound healing activity of Vernonia arborea Buch.-Ham. on Wistar rats of either sex. In excision wound model, treatment was continued till the complete healing of the wound whereas in incision and dead space wound models the treatment was continued for 10 days. For topical application, 5% w/w ointment of aqueous and methanol barks extracts were prepared in 2% sodium alginate and for oral administration suspensions containing 30 mg/ml of each of the extracts in 1% gum tragacanth were prepared. In excision and incision wound models, the control group of animals was left untreated and in dead space wound models the animals were treated with 1 ml of 1% gum tragacanth/kg b.w. The healing of the wound was assessed by the rate of wound contraction, period of epithelialisation, skin breaking strength, granulation strength, dry granulation tissue weight, hydroxyproline estimation and histopathology of the granulation tissue. Aqueous and methanol barks extracts promoted the wound healing activity significantly in all the wound models studied. High rate of wound contraction, decrease in the period for epithelialisation, high skin breaking strength and granulation strength, increase in dry granulation tissue weight, elevated hydroxyproline content and increased collagenation in histopathological section were also observed when compared to the control group of animals. Methanol extract possesses better wound healing property than the aqueous extract.|
|Appears in Collections:||NPR Vol.8(1) [January-February 2009]|
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