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IJBB Vol.40(3) [June 2003] >

Title: QSAR of peripheral benzodiazepine receptor ligand 2-phenylimidazo- [1,2-a]pyridine derivatives with physico-chemical parameters
Authors: Roy, Kunal
De, A U
Sengupta, Chandana
Issue Date: Jun-2003
Publisher: CSIR
Abstract: QSAR of the binding affinities of [2-phenylimidazo[1,2-a]pyridin-3-yl]acetamide derivatives (Fig. 1) with central and peripheral (from cortex and ovary) benzodiazepine receptors has been explored using physico-chemical parameters. Attempt has been made to explore the structural and/or physico-chemical requirements of the compounds that are responsible for the selective action against peripheral benzodiazepine receptors over central ones. The results indicate that the presence of bi-substitution on the carboxamido nitrogen, presence of substitutions at X and Y positions, especially, chloro substitution at X position, and presence of chloro substitution at Z position in presence of lipophilic X and/or Y substitutions increase selectivity for binding affinity with peripheral benzodiazepine receptors over central ones.
Page(s): 203-208
ISSN: 0301-1208
Source:IJBB Vol.40(3) [June 2003]

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