|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.40 [2003] >
IJBB Vol.40(3) [June 2003] >
| Title: | QSAR of peripheral benzodiazepine receptor ligand 2-phenylimidazo- [1,2-a]pyridine derivatives with physico-chemical parameters |
| Authors: | Roy, Kunal
De, A U
Sengupta, Chandana |
| Issue Date: | Jun-2003 |
| Publisher: | CSIR |
| Abstract: | QSAR of the binding affinities of [2-phenylimidazo[1,2-a]pyridin-3-yl]acetamide derivatives (Fig. 1) with central and peripheral (from cortex and ovary) benzodiazepine receptors has been explored using physico-chemical parameters. Attempt has been made to explore the structural and/or physico-chemical requirements of the compounds that are responsible for the selective action against peripheral benzodiazepine receptors over central ones. The results indicate that the presence of bi-substitution on the carboxamido nitrogen, presence of substitutions at X and Y positions, especially, chloro substitution at X position, and presence of chloro substitution at Z position in presence of lipophilic X and/or Y substitutions increase selectivity for binding affinity with peripheral benzodiazepine receptors over central ones. |
| Page(s): | 203-208 |
| ISSN: | 0301-1208 |
| Source: | IJBB Vol.40(3) [June 2003]
|
|
