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|Title:||Chronic cold stress-induced alterations in brush border membrane composition and enzyme activities in rat intestine|
|Abstract:||The effect of chronic cold stress on the composition and function of rat intestinal brush border membrane (BBM) was studied. Various lipid fractions from intestinal BBM viz. cholesterol (p<0.01), phospholipids (p<0.01), triglycerides (p<0.05) and gangliosides (p<0.05) were significantly reduced in cold stressed animals, as compared to controls. Analysis of membrane saccharide content revealed a significant increase in sialic acid (25%) and hexosamine (36%) contents and a re-duction in fucose (19%) content in cold stressed rats. Determination of various enzyme activities in BBM showed signifi-cantly enhanced activities of alkaline phosphatase (p<0.01), lactase (p<0.001) and leucine aminopeptidase (p<0.001), whereas sucrase activity was reduced (p<0.05) under these conditions. The magnitude and site of these alterations across the crypt-villus axis varied from enzyme to enzyme. These findings suggest that chronic cold stress results in profound altera-tions in intestinal BBM. Altered structure and function of intestinal BBM may play a role in stress-induced derangements in gastrointestinal tract.|
|Appears in Collections:||IJBB Vol.40(3) [June 2003]|
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