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Title: Identification of serotonin-sensitive aryl acylamidase activity with cobra venom acetylcholinesterase
Authors: Rajesh, Ramanna V
Balasubramanian, Aiylam S
Boopathy, Rathanam
Issue Date: Apr-2003
Publisher: CSIR
Abstract: Acetylcholinesterase purified from cobra (Naja naja) venom exhibits a serotonin-sensitive aryl acylamidase activity. Both acetylcholinesterase and aryl acylamidase activities co-eluted in column chromatographic procedures (Sephadex G-75 and Zinc-Sepharose), co-migrated on polyacrylamide gel electrophoresis, co-immunoprecipitated by anti-snake venom anti-body and showed the same heat denaturation profile at 40°C. Further, several potent acetylcholinesterase inhibitors at differ-ent concentrations inhibited the cholinesterase and aryl acylamidase activities to the same extent. It is concluded that in co-bra venom, acetylcholinesterase is associated with a serotonin-sensitive aryl acylamidase activity similar to earlier observa-tions made with acetylcholinesterase from different sources.
Page(s): 92-97
ISSN: 0301-1208
Appears in Collections:IJBB Vol.40(2) [April 2003]

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