NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.40 [2003] >
IJBB Vol.40(1) [February 2003] >


Title: Computational analysis of evolutionary divergence of scorpion toxins
Authors: Upadhyay, R K
Issue Date: Feb-2003
Publisher: CSIR
Abstract: Conserved and consensus sequences of several members of scorpion toxin families have been analyzed. Multiple sequence alignment define the highly conserved residues that play important structural role in formation of toxin sub-groups. Scorpion toxins have characteristic feature in signature pattern {(GA)}- K-C {(LIVM)}-X (2)- K- C- C-X-C) }, where lysine and cysteine residues are well conserved in the polypeptide. The toxins show two major groups, one with conserved active region GKCMNKGKC and second with CTPK. There is variability in position of lysine and arginine in different toxins. Most of the scorpion toxins contain six conserved cysteines involved in disulphide bonds. From the evolutionary analysis it is concluded that Leiurus is a primitive ancestral species from which probably various toxins have evolved during the evolution.
Page(s): 51-58
ISSN: 0301-1208
Source:IJBB Vol.40(1) [February 2003]

Files in This Item:

File Description SizeFormat
IJBB 40(1) 51-58.pdf689.8 kBAdobe PDFView/Open
 Current Page Visits: 445 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 556153 since 06-Feb-2009  Last updated on 15-Jul-2014Webmaster: nopr@niscair.res.in