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IJBB Vol.41(6) [December 2004] >


Title: A theoretical study of the stability of DNA binding with cis/trans platin
Authors: Srivastava, Seema
Khan, Irfan Ali
Srivastava, Shinoo
Gupta, Vishwambhar Dayal
Keywords: cis/trans Platin
nucleation parameter
co-operativity
λ-point anomaly
transition profile
DNA binding
heat capacity
Issue Date: Dec-2004
Publisher: CSIR
Abstract: Both cis- and trans-platins are known to form intra- and interstrand cross-linking with DNA. Since the nature and strength of binding is different, it makes their efficacy as anti-tumour drug different. In the present communication, we report theoretical analysis by using an amended Zimm and Bragg theory, to explain the melting behaviour and heat capacity of DNA with and without platin binding. The sharpness of transition has been examined in terms of half width and sensitivity parameter (ΔH/σ). The experimental measurements of Pilch et al (J Mol Biol 2000, 296, 803) and Ctirad and Brabec (J Biol Chem 2001, 276, 9655) have been used.
Page(s): 305-310
ISSN: 0301-1208
Source:IJBB Vol.41(6) [December 2004]

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