Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/3715
Title: Polyunsaturated fatty acids inhibit mouse hepatic glucocorticoid receptor activation in vitro
Authors: Ranhotra, H S
Sharma, R
Keywords: Fatty acids
mice
liver
activation
glucocorticoid receptor
Issue Date: Oct-2004
Publisher: CSIR
Abstract: The effect of saturated fatty acids (SFAs) stearic and palmitic acids and polyunsaturated fatty acids (PUFAs) oleic, linoleic and arachidonic acids was studied on in vitro heat activation of mouse hepatic glucocorticoid receptor (GR) complex, as assessed by binding to DNA-cellulose and purified nuclei. Significant dose-dependent inhibition of heat activation of hormone-receptor com-plex by the PUFAs was observed. Linoleic and arachidonic acids were found to be more potent (caused ~70% inhibition maximally at 160 μM) inhibitors of GR heat activation, compared to oleic acid (~38% inhibition at 40 μM). However, stearic and palmitic acids were unable to modulate GR heat activation, suggesting that the unsaturated moieties in PUFAs are possibly the important determinants of receptor activation. Thus, our study shows an inhibitory effect of PUFAs on in vitro hepatic GR activation.
Description: 246-249
URI: http://hdl.handle.net/123456789/3715
ISSN: 0301-1208
Appears in Collections:IJBB Vol.41(5) [October 2004]

Files in This Item:
File Description SizeFormat 
IJBB 41(5) 246-249.pdf135.06 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.