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IJBB Vol.41(4) [August 2004] >

Title: Effect of aspartame on circadian oscillations of calcium and inorganic phosphorus in rats
Authors: Rajasekar, P
Manivasagam, T
Keywords: Aspartame
circadian rhythm
inorganic phosphorus.
Issue Date: Aug-2004
Publisher: CSIR
Abstract: The effect of aspartame on circadian rhythms of calcium and inorganic phosphorus levels was studied in rats. Acrophase delays in calcium rhythms and advances in inorganic phosphorus rhythms and alteration in mesor values in both rhythms were observed in aspartame-treated rats. However, no change in amplitude values was observed. Oral administration of aspartame leads to increased levels of aspartate in the brain, which could alter the characteristics of calcium and inorganic phosphorus rhythms, possibly by modulating transmission in several areas/nuclei in brain, including retinohypothalamic tract (RHT) and suprachiasmatic nuclei (SCN).
Page(s): 188-190
ISSN: 0301-1208
Source:IJBB Vol.41(4) [August 2004]

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