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Title: Effects of Rumex patientia L. extract on some drug-metabolizing enzymes in rat liver
Authors: Silig, Yavuz
Cetinkaya, Oge
Demirezer, L Omur
Keywords: Rumex patientia
Drug-metabolizing enzymes
Cyto-chrome P4502E1
Glutathione-S-transfrase
NADPH-cytochrome c reductase
NADH-cytochrome b5 reductase
Issue Date: Feb-2004
Publisher: CSIR
Abstract: The effect of aqueous extract from the roots of Rumex patientia L. (Polygonaceae) (D-1), a traditional Turkish medicine used as a laxative and cholagogue, on drug-metabolizing enzymes, such as cytochrome P4502E1, NADPH cytochrome c reductase, NADH cytochrome b5 reductase and glutathione-S-transferase (GST); and serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were studied in male Wistar albino rat liver. A significant increase was observed in cytochrome P4502E1 and GST activities, but not in NADPH-cytochrome c reductase and NADH-cytochrome b5 reductase activities. Serum AST and ALT activities were found within the normal laboratory range values. The results demonstrated that the aqueous extract of R. patientia triggers induction of cytochrome P4502E1 in liver and cytosolic GST activity.
Page(s): 45-47
ISSN: 0301-1208
Source:IJBB Vol.41(1) [February 2004]

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