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IJBB Vol.41(1) [February 2004] >


Title: Combined effect of alcohol and cigarette smoke on lipid peroxidation and antioxidant status in rats
Authors: Bindu, M P
Annamalai, P T
Keywords: Alcohol
Cigarette smoke
Lipid peroxidation
Antioxidant status
Issue Date: Feb-2004
Publisher: CSIR
Abstract: The effect of long-term administration of alcohol and cigarette smoke independently and both in combination on lipid peroxidation and antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione-S-transferase (GST) was studied in liver, kidney, heart and lungs of albino rats. The levels of peroxidation products viz., malondialdehyde, hydroperoxides and conjugated dienes were increased in all the tissues of alcohol administered and smoke-exposed rats. Activities of SOD and CAT were decreased in alcohol-treated and alcohol and smoke combination groups, but increased in smoke-exposed group. Activities of GPx and GST have shown an increase, while concentration of reduced glutathione was found decreased in all the three groups.
Page(s): 40-44
ISSN: 0301-1208
Source:IJBB Vol.41(1) [February 2004]

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