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Title: Genetic variants of β-casein in cattle and buffalo breeding bulls in Karnataka state of India
Authors: Ramesha, K P
Rao, Akhila
Basavaraju, M
Alex, Rani
Kataktalware, M A
Jeyakumar, S
Varalakshmi, S
Keywords: A1 and A2 allele;ACRS;Breeding bulls;β-casein;PCR-RFLP
Issue Date: Apr-2016
Publisher: NISCAIR-CSIR, India
Abstract: Among the genetic variants of bovine β-casein gene (CSN2), A1 and A2 are the most common. β-Casein contains 209 amino acids and A1 and A2 variants differ only at position 67 in the amino acid chain CAT, which is histidine in A1, and CCT, which is proline in case of A2. Various studies suggest that A1 casein present in milk is likely to cause health problems. The present study involved screening of 391 bulls belonging to seven breeds of cattle and two breeds of buffaloes from different regions of Karnataka for genetic variants A1 and A2in β-casein gene using ACRS (amplification created restriction sites) method with Taq Irestriction enzyme. The results indicated that A2 allele is fixed in Deoni and Khillar breed of cattle and both the buffalo breeds (Murrah & Surti). It was observed that the frequency of A1 allele was very low in Malnad Gidda (0.014), Kasargod variety (0.042) and Jersey (0.077), while the frequency of A1 allele in Holstein Friesian and Holstein Friesian crossbred males was 0.169 and 0.294, respectively.
Page(s): 178-181
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Appears in Collections:IJBT Vol.15(2) [April 2016]

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