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Title: Antibacterial activity of some unsymmetrical diorganyltellurium(IV) dichlorides
Authors: Soni, Daya
Gupta, Prabhat K
Kumar, Yatindra
Chandrashekhar, T G
Keywords: Unsymmetrical diorganyltellurium(IV) dichlorides
Antibacterial activity
Bacillus subtilis
Staphylo-coccus aureus
Escherichia coli
Pseudomonas aeruginosa
Salmonella sp.
Issue Date: Dec-2005
Publisher: CSIR
IPC CodeC12Q1/18
Abstract: Six unsymmetrical diorganyltellurium(IV) dichlorides RR'TeClâ‚‚ (where R= phenacyl-, 1-naphthacyl-, and styrylacyl- and R' = p-methoxyphenyl, p-hydroxyphenyl-, and 3-methyl-4-hydoxyphenyl-) were tested for their antibacterial activity against gram-positive (Bacillus subtilis ATCC 6633 and Staphylococcus aureus ATCC 25923) and gram-negative (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and Salmonella sp.) bacteria. Antibacterial activity was measured by disk diffu-sion method. Inhibition zones demonstrated that all the compounds showed good activity against gram-negative strains. Phenacyl (3-methyl-4-hydroxyphenyl) tellurium(IV) dichloride and naphthacyl (3-methyl-4-hydroxyphenyl) tellurium(IV) dichlo-ride showed significant activity against both gram-positive and gram-negative strains. Among the tested compounds, the former exhibited maximum activity against gram-positive bacteria, while the latter against all the bacteria under study and styrylacyl (p-methoxyphenyl) tellurium(IV) dichloride against all the three gram-negative bacteria.
Page(s): 398-400
ISSN: 0301-1208
Source:IJBB Vol.42(6) [December 2005]

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