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Title: Selective synthesis of 10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione using copper oxide nanoparticles for potential inhibitors of β-ketoacyl-[acyl-carrier-protein] synthase III of Mycobacterium tuberculosis
Authors: Patil, Kirti T
Walekar, L S
Undare, S S
Kolekar, G B
Deshmukh, Madhukar B
Choudhari, P B
Anbhule, Prashant V
Keywords: Multicomponent reaction;Copper oxide nanoparticles;β-ketoacyl-[acyl-carrier-protein] synthase III;Docking analysis
Issue Date: Sep-2016
Publisher: NISCAIR-CSIR, India
Abstract: A simple and selective synthesis of 10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione derivatives has been investigated by multicomponent reaction of aromatic aldehydes, 4-hydroxycoumarin and dimedone using copper oxide nanoparticles. All the synthesised coumarin derivatives have been screened for anti-tubercular activity. The virtual analysis of the synthesised derivatives have also been carried out against β-ketoacyl-[acyl-carrier-protein] synthase III. The inhibition of the β-ketoacyl-[acyl-carrier-protein] synthase III is confirmed from the docking study. The experimental results have shown that the compound 10,10-dimethyl-7-(3-nitrophenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)dione (MIC 6.25 μg/mL) is a good anti-tubercular agent and as good as standard streptomycin drug based on minimum inhibitory concentration.
Page(s): 1151-1159
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.55B(09) [September 2016]

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