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Title: Impact of inclusion complex formation on antibacterial, antioxidant and anthelmintic activities of some 4-arylidenamino-5-phenyl-4H-1,2,4-triazole-3-thiols
Authors: Nayak, Sashikanta
Panda, Sunakar
Keywords: Triazole-3-thiol;Inclusion complex;Antibacterial activity;Antioxidant activity;Anthelmintic activity
Issue Date: Sep-2016
Publisher: NISCAIR-CSIR, India
Abstract: Three different 4-arylidenamino-5-phenyl-4H-1,2,4-triazole-3-thiols have been synthesized and their inclusion complexes are prepared with β-cyclodextrin. The compounds and their inclusion complexes have been characterized by studying their physical and spectral properties. The determination of thermodynamic stability constant and standard free energy change indicates that inclusion complexes of the newly synthesized compounds are stable and their formation is thermodynamically allowed. Finally, the compounds and their inclusion complexes are screened for antibacterial, antioxidant and anthelmintic activities. It is found that inclusion complex formation increases the antibacterial, antioxidant and anthelmintic activities significantly as compared to naked compounds. The higher pharmacological activities have been explained in terms of enhanced solubility in the systemic circulation which makes them more available to specific tissues for better therapeutic efficacy.
Page(s): 1144-1150
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.55B(09) [September 2016]

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