Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/35365
Title: Synthesis of novel N,N-dimethyl-1-(5-methyl-2-arylimidazo[1,2-a]pyridin-3-yl)methanamine derivatives as potential antimicrobial agents
Authors: Desai, N C
Pandya, M R
Patel, B Y
Bhatt, M J
Karkar, T J
Keywords: Imidazo[1,2-a]pyridine;Phenacyl bromides;Antibacterial activity;Antifungal activity;SAR study;MIC
Issue Date: Sep-2016
Publisher: NISCAIR-CSIR, India
Abstract: The title compounds N,N-dimethyl-1-(5-methyl-2-arylimidazo[1,2-a]pyridin-3-yl)methanamines have been synthesized by reaction of α-haloketones with 6-methylpyridin-2-amine followed by a series of multistep reactions giving the targeted compounds (4a-l). All the synthesized compounds have been screened for their in vitro antibacterial activity against E. coli, S. aureus, P. aeruginosa, S. pyogenes and antifungal activity against C. albicans, A. niger and A. clavatus. The structures of the synthesized compounds have been confirmed by spectral data IR, 1H and 13C NMR and mass spectra. Investigation of antimicrobial activity reveals that the compounds 4b, 4c, 4d, 4e and 4j show significant activities against tested organisms as compared to standard drugs like ampicillin and griseofulvin.
Page(s): 1136-1143
URI: http://nopr.niscair.res.in/handle/123456789/35365
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.55B(09) [September 2016]

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