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|Title:||Povarov reaction, scope and limitations: Preparation of diversely heterocyclic tetrahydro-1H-cyclopenta[c]quinolines|
|Keywords:||Povarov reaction;Multicomponent reaction;Parallel synthesis;Cycloaddition;Imines;Alkenes;Diastereoselectivity;Scandium;Heterocycles;Tetrahydroquinolines;Aldehydes|
|Abstract:||Parallel synthesis of diverse heterocyclic-tetrahydro-1H-cyclopenta[c]quinolines in excellent yields and high endo diastereoselectivity has been described herein. These compounds are highly functionalized natural product-like tricyclic systems, which may be useful as biologically relevant targets. Fine tuning of the reaction conditions need to be performed depending on the nature and molecular structure of the heterocyclic aromatic carbaldehyde, as well as the choice of the Lewis acid catalyst. Synthesis of the heterocyclic aromatic aldehyde precursors of the Povarov Reaction is also described.|
|Appears in Collections:||IJC-B Vol.55B(09) [September 2016]|
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