Please use this identifier to cite or link to this item:
Title: Povarov reaction, scope and limitations: Preparation of diversely heterocyclic tetrahydro-1H-cyclopenta[c]quinolines
Authors: Niño, Patricia
Caba, Marta
Aguilar, Nuria
Terricabras, Emma
Albericio, Fernando
Fernàndez, Joan-Carles
Keywords: Povarov reaction;Multicomponent reaction;Parallel synthesis;Cycloaddition;Imines;Alkenes;Diastereoselectivity;Scandium;Heterocycles;Tetrahydroquinolines;Aldehydes
Issue Date: Sep-2016
Publisher: NISCAIR-CSIR, India
Abstract: Parallel synthesis of diverse heterocyclic-tetrahydro-1H-cyclopenta[c]quinolines in excellent yields and high endo diastereoselectivity has been described herein. These compounds are highly functionalized natural product-like tricyclic systems, which may be useful as biologically relevant targets. Fine tuning of the reaction conditions need to be performed depending on the nature and molecular structure of the heterocyclic aromatic carbaldehyde, as well as the choice of the Lewis acid catalyst. Synthesis of the heterocyclic aromatic aldehyde precursors of the Povarov Reaction is also described.
Page(s): 1117-1130
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.55B(09) [September 2016]

Files in This Item:
File Description SizeFormat 
IJCB 55B(9) 1117-1130.pdf326.13 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.