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|Title:||Two directional approach to spirocyclic ethers via Grignard reaction and ring-closing metathesis|
|Keywords:||Grignard reaction;Grubb’s catalyst;Metathesis;Spiro compounds;Pyran derivatives|
|Abstract:||Diverse and intricate bis-spirocycles have been assembled via a Grignard reaction and ring-closing metathesis (RCM) as key steps. Readily available starting materials have been used and mild reaction conditions employed to generate a variety of intricate spirocyclic ethers containing pyran ring system. The scope of this methodology has then been expanded by synthesizing a spiro-dihydrofuran derivative.|
|Appears in Collections:||IJC-B Vol.55B(09) [September 2016]|
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|IJCB 55B(9) 1099-1106.pdf||216.32 kB||Adobe PDF||View/Open|
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