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Title: Biochemical changes in erythrocyte membrane in uncontrolled type 2 diabetes mellitus
Authors: Reshamwala, Shamlan M S
Patil, Neela D
Keywords: Uncontrolled type 2 diabetes mellitus;Erythrocyte membrane;Glycated haemoglobin;Na⁺-K⁺-ATPase;Mg²⁺-ATPase;Lipid peroxidation;Cholesterol;Phospholipid
Issue Date: Aug-2005
Publisher: CSIR
IPC Code: A61K38/42; A61P7/00
Abstract: The levels of lipid peroxidation and alterations in lipid composition and ATPase activities were determined in erythrocyte plasma membrane of uncontrolled type 2 diabetes mellitus (DM) patients. The study groups consisted of 30 patients (16 males, 14 females) attending the Out Patients’ Department of Lokmanya Tilak Municipal General Hospital, Mumbai, and 23 age- and sex-matched control subjects (15 males, 8 females). Glycated haemoglobin (an index of long-term glycaemic control), erythrocyte membrane cholesterol, phospholipid and cholesterol to phospholipid molar ratio, lipid peroxidation products in the form of thiobarbituric acid-reactive substances (TBARS), and Na⁺-K⁺-ATPase activity were found to be significantly increased, and Mg²⁺-ATPase activity significantly decreased, in the diabetic subjects, as compared to controls. The study suggests that biochemical changes in the erythrocyte membrane may be involved in the pathophysiology of type 2 DM.
Page(s): 250-253
ISSN: 0301-1208
Appears in Collections:IJBB Vol.42(4) [August 2005]

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