Please use this identifier to cite or link to this item:
http://nopr.niscair.res.in/handle/123456789/3531
Title: | Biochemical changes in erythrocyte membrane in uncontrolled type 2 diabetes mellitus |
Authors: | Reshamwala, Shamlan M S Patil, Neela D |
Keywords: | Uncontrolled type 2 diabetes mellitus;Erythrocyte membrane;Glycated haemoglobin;Na⁺-K⁺-ATPase;Mg²⁺-ATPase;Lipid peroxidation;Cholesterol;Phospholipid |
Issue Date: | Aug-2005 |
Publisher: | CSIR |
IPC Code: | A61K38/42; A61P7/00 |
Abstract: | The levels of lipid peroxidation and alterations in lipid composition and ATPase activities were determined in erythrocyte plasma membrane of uncontrolled type 2 diabetes mellitus (DM) patients. The study groups consisted of 30 patients (16 males, 14 females) attending the Out Patients’ Department of Lokmanya Tilak Municipal General Hospital, Mumbai, and 23 age- and sex-matched control subjects (15 males, 8 females). Glycated haemoglobin (an index of long-term glycaemic control), erythrocyte membrane cholesterol, phospholipid and cholesterol to phospholipid molar ratio, lipid peroxidation products in the form of thiobarbituric acid-reactive substances (TBARS), and Na⁺-K⁺-ATPase activity were found to be significantly increased, and Mg²⁺-ATPase activity significantly decreased, in the diabetic subjects, as compared to controls. The study suggests that biochemical changes in the erythrocyte membrane may be involved in the pathophysiology of type 2 DM. |
Page(s): | 250-253 |
URI: | http://hdl.handle.net/123456789/3531 |
ISSN: | 0301-1208 |
Appears in Collections: | IJBB Vol.42(4) [August 2005] |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
IJBB 42(4) 250-253.pdf | 61.75 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.