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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.42 [2005] >
IJBB Vol.42(4) [August 2005] >
| Title: | Biochemical changes in erythrocyte membrane in uncontrolled type 2 diabetes mellitus |
| Authors: | Reshamwala, Shamlan M S
Patil, Neela D |
| Keywords: | Uncontrolled type 2 diabetes mellitus
Erythrocyte membrane
Glycated haemoglobin
Na⁺-K⁺-ATPase
Mg²⁺-ATPase
Lipid peroxidation
Cholesterol
Phospholipid |
| Issue Date: | Aug-2005 |
| Publisher: | CSIR |
| IPC Code: | A61K38/42; A61P7/00 |
| Abstract: | The levels of lipid peroxidation and alterations in lipid composition and ATPase activities were determined in erythrocyte plasma membrane of uncontrolled type 2 diabetes mellitus (DM) patients. The study groups consisted of 30 patients (16 males, 14 females) attending the Out Patients’ Department of Lokmanya Tilak Municipal General Hospital, Mumbai, and 23 age- and sex-matched control subjects (15 males, 8 females). Glycated haemoglobin (an index of long-term glycaemic control), erythrocyte membrane cholesterol, phospholipid and cholesterol to phospholipid molar ratio, lipid peroxidation products in the form of thiobarbituric acid-reactive substances (TBARS), and Na⁺-K⁺-ATPase activity were found to be significantly increased, and Mg²⁺-ATPase activity significantly decreased, in the diabetic subjects, as compared to controls. The study suggests that biochemical changes in the erythrocyte membrane may be involved in the pathophysiology of type 2 DM. |
| Page(s): | 250-253 |
| ISSN: | 0301-1208 |
| Source: | IJBB Vol.42(4) [August 2005]
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