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Title: Augmentation of capsaicin-induced vasorelaxation of superior mesenteric artery (Capra hircus) in acidosis: role of TRPV1 channels
Authors: Mohanty, Ipsita
Nayak, Nihar R
Parija, Subas C
Keywords: Acidosis;Endothelial TRPV1;Capsaicin;Goat superior mesenteric artery
Issue Date: Oct-2016
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: A01K 14/00, A61K 36/00
Abstract: Capsaicin is known to induce vasorelaxation through activation of the transient receptor potential cation channel subfamily V member 1(TRPV1). However, TRPV1 is a nonselective cation channel and can be activated by a wide variety of exogenous and endogenous stimuli, including acidic conditions. The present study investigated the effect of changes in pH on capsaicin-induced vasorelaxation in both endothelium intact and denuded goat superior mesenteric artery (GSMA) rings, using a highly sensitive isometric force transducer. There was a significant increase in capsaicin-induced vasorelaxation in nor adrenaline (NA)-precontracted GSMA rings at acidic pHs of 6.8 (44.71±4.85%) and pH 6.0 (46.43±2.59%), compared to a physiological level of pH of 7.4 (33.25±2.62%). Although not completely abrogated, endothelium denudation and ruthenium red (RR) treatment significantly attenuated capsaicin-induced vasorelaxation at all pH levels. These data together suggest that, while other minor endothelium/TRVP1-independent mechanisms may exist, augmentation of capsaicin-induced vasorelaxation in acidosis is primarily endothelium-dependent and mediated through TRPV1 channels.
Page(s): 625-631
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.15(4) [October 2016]

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