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Title: Ameliorative effect of glabridin, a main component of Glycyrrhiza glabra L. roots in streptozotocin induced Type 1 diabetes in male albino rats
Authors: El-Ghffar, Eman A Abd
Keywords: Licorice;Blood glucose;Liver enzymes;Lipid profile;Kidney function;Cytokine;Diabetic rats
Issue Date: Oct-2016
Publisher: NISCAIR-CSIR, India
IPC Code: IPC Int. Cl.8: A61K 36/00, A61B 5/15, C12N 9/00, C12N 7/42, A01D 13/37, A01D 13/00, A01D 16/02
Abstract: Glabridin (component of Licorice), a major flavonoid of Glycyrrhiza glabra L. (Fabaceae), is commonly used in the treatment of cardiovascular and central nervous system diseases. Also, it has been associated with a wide range of biological properties such as antioxidant, anti-inflammatory, estrogenic and anti-osteoporotic. Here, we investigated the antidiabetic effects of oral treatment with glabridin on streptozotocin (STZ)-induced diabetic rats. Type 1 diabetes was induced in male albino rats by a single intraperitoneal injection of STZ (60 mg/kg body weight). Diabetes appeared after 1-3 days after STZ injection. The animals were randomly divided into6 groups (7 animals each) as follows; Group 1: Normal control group (negative control group); Group 2 & 3: glabridin-treated control groups (25&50 mg/kg body weight); Group 4:STZ diabetic group (positive control group); Group 5 & 6:glabridin treated diabetic groups(25&50 mg/kg body weight). In normal rats, no harmful effects were detected after orally administration of both doses of glabridin on all parameters measured.The anti-diabetic activity of glabridin (especially high dose) was mediated through significantly increased the body weight gain, enzymic/non-enzymic antioxidants and HDL-cholesterol, and significantly decreased relative organ weights, serum glucose, lipid profiles, lipid peroxidation (LPO), pro-inflammatory cytokine, liver and kidney functions. The present study indicated that the anti-inflammatory/anti-oxidant activity of glabridin (especially high dose) may have beneficial effects against complications shown in STZ diabetic rats.
Page(s): 570-579
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.15(4) [October 2016]

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