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Title: Antimicrobial secondary metabolites from marine fungi: A mini review
Authors: Bajpai, Vivek K.
Keywords: Marine fungi;Antimicrobials;Secondary metabolites;Mycotoxins;Ecology
Issue Date: Sep-2016
Publisher: NISCAIR-CSIR, India
Abstract: Marine fungi living in a stressful habitat, under cold, lightless and high pressure conditions have shown significant importance as new promising sources of biologically active products. These marine fungi produce fascinating and structurally complex natural products. To date, only a minimum amount of microorganisms have been investigated for the production of bioactive marine metabolites with unique structural skeletons. Marine microorganism based secondary metabolites are considered to be a burning area of research in few last decades. Many of such compounds have been proven to be anti-bacterial, anti-fungal, anti-algal, anti-HIV, anti-helminthic, anti-protozoan, anti-tumor and anti-allergic agents. Marine fungi have been reported to be the producers of such compounds owing to their multitude of defense mechanisms and complex metabolism. Although a number of natural products have been isolated from marine microbial flora, a limited number of compounds have reached to the clinical trial levels as a drug. Herein this review we have discussed recent studies on the isolation, characterization and the pharmacological significances of anti-bacterial, anti-fungal and anti-infective agents of marine fungal origin. Further, the clinical status of such compounds has also been discussed in comparison with those derived from their terrestrial counterparts. This review provides research insights so far conducted on marine fungi with aspects to provide baseline information on marine flora-based antimicrobial research which may assist in context to provide cheaper, safer, and potent medicinal alternatives to challenge the dreadful human disease.
Page(s): 1067-1075
ISSN: 0975-1033 (Online); 0379-5136 (Print)
Appears in Collections:IJMS Vol.45(09) [September 2016]

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